Condensation of 2-Benzoyl-1-cyano-1,2-dihydroisoquinoline with Electrophilic Alkenes Under Phase-transfer Catalytic (PTC) Conditions†
Abstract
Condensation of Reissert compound 1 with electrophilic alkenes 2 carried out in the presence of 50% aqueous sodium hydroxide and benzyltriethylammonium chloride (TEBAC) as a catalyst, affords 1-(2-substituted-ethyl)isoquinolines 3 and/or 4.