SCHEDULED MAINTENANCE
In the presence of an excess of LDA, the tandem deprotonation–alkylation reaction of 1-cyanomethyl-5-fluorouracil with epibromohydrin gives the novel dihydropyrrolo[1,2-c]pyrimidinedione 4 as a mixture of diastereoisomers.
G. Grangier-McMath, D. J. Aitken, D. Guillaume, A. Chiaroni, C. Riche and H. Husson, J. Chem. Res. (S), 1998, 260 DOI: 10.1039/A705631A
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