Dramatic increase of the DNA cleavage activity of Cu(Clip-phen) by fixing the bridging linker on the C3 position of the phenanthroline units
Abstract
The synthesis of a new ligand with two phenanthrolines bridged on their C3 carbon by a serinol is reported; Cu(3-Clip-phen) cleaves DNA more efficiently than the parent Cu(2-Clip-phen) bridged on the C2 carbon.