Binding of D-serine-terminating cell-wall analogues to glycopeptide antibiotics

Abstract

Binding studies of –L-Lys-D-Ala-D-Ser-terminating ligands, used as model systems for cell-wall precursors found in VanC resistant bacteria, with vancomycin, chloroeremomycin and teicoplanin show that they bind to these glycopeptides in a similar manner as –L-Lys-D-Ala-D-Ala-terminating ligands, but that the binding constants are one to two orders of magnitude lower.