Issue 4, 1998

Direct versatile route to conformationally constrained glutamate analogues

Abstract

Novel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid; using a bicyclic lactam template, diastereocontrolled and sequential modification of the pyrrolidine ring is possible, allowing a versatile access to several glutamate and kainoid analogues; variations in the C(2)H–C(3)H coupling constants were observed depending upon the nature of remote substituents on the heterocyclic ring, consistent with modification of the ring conformation.

Article information

Article type
Paper

Chem. Commun., 1998, 461-462

Direct versatile route to conformationally constrained glutamate analogues

J. Dyer, M. G. Moloney and S. Keeling, Chem. Commun., 1998, 461 DOI: 10.1039/A708429C

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