Asymmetric tandem reactions based on nitroalkenes: a one-pot construction of functionalized chiral bicycles by a three-component reaction
Abstract
Asymmetric tandem cycloaddition of a chiral carbohydrate nitroalkene with ethyl vinyl ether in the presence of electron- withdrawing alkenes produces a facile assembly of bicyclic systems, which can further be selectively cleaved to give homologated carbohydrates.