Modeling the active sites of bacteriophage T7 lysozyme, bovine 5-aminolevulinate dehydratase, and peptide deformylase: synthesis and structural characterization of a bis(pyrazolyl)(thioalkoxy)hydroborato zinc complex, [(Ph2CHS)BpBut,Pri]ZnI

Abstract

Insertion of thiobenzophenone into a B–H bond of [Bp^But,Pri]ZnI achieves the synthesis of [(Ph₂CHS)Bp^But,Pri]ZnI, a complex in which the in situ generated [NNS] donor ligand models the binding of the histidine and cysteine residues at the active sites of bacteriophage T7 lysozyme, bovine 5-aminolevulinate dehydratase and peptide deformylase.