Issue 11, 1997

Total synthesis of (-)-PA-48153C (pironetin) utilising l-quebrachitol as a chiral building block

Abstract

The chiral and stereoselective synthesis of (-)-PA-48153C (pironetin) 1, a novel immunosuppressant, is described; the acyclic portion possessing four contiguous chiral centres in 1 was constructed stereoselectively from L-quebrachitol and the 2-pyranone moiety was prepared from L-malic acid.

Article information

Article type
Paper

Chem. Commun., 1997, 1043-1044

Total synthesis of (-)-PA-48153C (pironetin) utilising l-quebrachitol as a chiral building block

N. Chida, M. Yoshinaga, T. Tobe and S. Ogawa, Chem. Commun., 1997, 1043 DOI: 10.1039/A701404J

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