New methoxy-substituted 9-phenylxanthen-9-ylamine linkers for the solid phase synthesis of protected peptide amides

Abstract

New methoxy-substituted 9-phenylxanthen-9-ylamine linkers are described for the solid phase synthesis of peptide amides via the Fmoc strategy; depending on the cleavage conditions, the peptide amides can be cleaved rapidly and in high purity in their protected or deprotected forms.