Amperometric Drug Response of a DNA Membrane Electrode Based on the Enzyme-mimic Catalytic Activity of a DNA–Copper(II) Complex

Abstract

The catalytic activity of a DNA–Cu ^II complex for the oxidation of aminoethanethiol is reversibly inhibited by intercalation with the DNA-binding drug quinacrine, in a concentration dependent manner,which could be detected via an amperometric signal by using a DNA–Cu ^II complex entrapping hydrogel and an oxygen electrode.