Synthesis of isoindolinones via carbonylative cyclisation of 2-(2-bromophenyl)-2-oxazolines by a bimetallic palladium–nickel catalyst system
Abstract
2-(2-Bromophenyl)-2-oxazolines react with carbon monoxide (3 atm) in alcohol in the presence of a catalytic amount of a bimetallic palladium–nickel catalyst to give the corresponding isoindolinones in high yields.