Issue 2, 1995

Synthetic applications of arenetricarbonylchromium(0) complexes: the synthesis of polyfunctionalised thiophenes

Abstract

Lithiation of thiophenetricarbonylchromium(0) complexes with butyllithium occurs preferentially at C-2/5 but when these are blocked, 3/4 lithiation is facile. Combinations of a bulky silyl (Pri3Si or ButMe2Si) blocking group at C-2/5 and remote lithiation/electrophilic quench of C-3/4 followed by desilylation/lithiation/electrophilic quench allowed the synthesis of 2,3-, 2,3,5- and 2,3,4,5-polysubstituted thiophene complexes and their derived free thiophenes.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1995, 97-104

Synthetic applications of arenetricarbonylchromium(0) complexes: the synthesis of polyfunctionalised thiophenes

M. S. Loft, T. J. Mowlem and D. A. Widdowson, J. Chem. Soc., Perkin Trans. 1, 1995, 97 DOI: 10.1039/P19950000097

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