Conformational analysis of the erythromycin analogues azithromycin and clarithromycin in aqueous solution and bound to bacterial ribosomes
Abstract
The conformations of erythromycin A 9-ketone, azithromycin and Clarithromycin free in aqueous solution and weakly bound to bacterial ribosomes are determined using ROESY and transferred NOESY 1H NMR experiments.