Issue 8, 1995

Investigation of the stereochemistry of the tri- and tetra-ketide hydroxyacyl intermediates in the biosynthesis of the polyketide aspyrone in Aspergillus malleus using deuterium labelling and deuterium NMR spectroscopy

Abstract

Following administration of both enantiomers of the hydroxyacyl tri- and tetra-ketide intermediates in the biosynthesis of aspyrone labelled with deuterium to Aspergillus melleus, it is shown by 2H NMR that in each case only the (S)-isomer is incorporated intact into the natural product.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1995, 859-860

Investigation of the stereochemistry of the tri- and tetra-ketide hydroxyacyl intermediates in the biosynthesis of the polyketide aspyrone in Aspergillus malleus using deuterium labelling and deuterium NMR spectroscopy

A. M. Hill, A. Jacobs and J. Staunton, J. Chem. Soc., Chem. Commun., 1995, 859 DOI: 10.1039/C39950000859

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements