Issue 2, 1995

The biosynthesis of tropic acid: the (R)-D-phenyllactyl moiety is processed by the mutase involved in hyoscyamine biosynthesis in Datura stramonium

Abstract

Incubations of (R)-D-phenyl[2-13C, 2H]lactic acid 5a and (S)-L-phenyl[2-13C, 2H]lactic acid 5b with transformed root cultures of Datura stramonium have revealed that the 13C–2H bond is retained, intact at C-3 of the tropate moiety of hyoscyamine, only in the case of the (R)-D enantiomer 5a( the deuterium is lost from the (S)-L-enantiomer 5b); therefore, it is the (R)-D-phenyllactate moiety of littorine which is the enantiomer processed by the mutase in hyoscyamine biosynthesis.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1995, 127-128

The biosynthesis of tropic acid: the (R)-D-phenyllactyl moiety is processed by the mutase involved in hyoscyamine biosynthesis in Datura stramonium

N. C. J. E. Chesters, D. O'hagan and R. J. Robins, J. Chem. Soc., Chem. Commun., 1995, 127 DOI: 10.1039/C39950000127

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