A four-step synthesis of N(a)-methylervitsine involving the nucleophilic addition of the enolate derived from acetylindole 2 to pyridinium salt 3, with subsequent C6H5SeBr-promoted cyclization of the resulting 1,4-dihydropyridine and further elaboration of the exocyclic 20E-ethylidene and 16-methylene substituents, is reported.
M. L. Bennasar, B. Vidal and J. Bosch, J. Chem. Soc., Chem. Commun., 1995, 125 DOI: 10.1039/C39950000125
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