Estimation and determination of steroid solubility in supercritical carbon dioxide
Abstract
The solubility of ten steroids in supercritical carbon dioxide is reported over a range of temperatures (35–100 °C) and pressures (84–231 kg cm–2). The solubility of testosterone, determined in this work, compares favourably with solubility data previously reported. The use of the solubility parameter and a hydrophobicity term (log P), has been shown to provide a qualitative estimate of steroid solubility.