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Issue 16, 1994
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The fungal biosynthesis of 3-nitropropionic acid: is the decarboxylation of L-nitrosuccinate an enzymatic reaction?

Abstract

In vitro enzymatic hydrolysis of diethyl (RS)-nitrosuccinate 2c by pig liver esterase at pH 7.8 affords 3-nitropropionic acid 1 indicating that the decarboxylation of (RS)-nitrosuccinate 2b is spontaneous under physiological conditions. In the in vivo synthesis of 1 from L-aspartate by cells of Penicillium atrovenetum, which involves oxidation of L-aspartate to nitrosuccinic acid, the decarboxylation of the nitrosuccinate may not require a specific biological catalyst.

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Article type: Paper
DOI: 10.1039/P19940002297
Citation: J. Chem. Soc., Perkin Trans. 1, 1994,0, 2297-2299
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    The fungal biosynthesis of 3-nitropropionic acid: is the decarboxylation of L-nitrosuccinate an enzymatic reaction?

    R. L. Baxter, S. L. Smith, J. R. Martin and A. B. Hanley, J. Chem. Soc., Perkin Trans. 1, 1994, 0, 2297
    DOI: 10.1039/P19940002297

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