Efficient optical resolution of cis-4-methylcyclohex-4-ene-1,2-dicarboxylic anhydride, cis-4- methylcyclohex-4-ene-1,2-dicarboximide, and their derivatives by complexation with optically active host compounds derived from tartaric acid

Abstract

Optically pure enantiomers of cis-4-methylcyclohex-4-ene-1,2-dicarboxylic anhydrides, cis-4-methylcyclohex-4-ene-1,2-dicarboximides and 3-oxabicyclo[4.3.0]non-7-en-2-ones have been obtained by optical resolution through enantioselective inclusion complexation with optically active host compounds derived from tartaric acid. Kinetic resolution of cyclohex-4-ene-1,2-dicarboximides and cyclohexane-1,2-dicarboximides by way of enantioselective hydrolysis is also reported.