New general synthesis of organophosphorus P–F compounds via reaction of azolides of phosphorus acids with acyl fluorides: novel route to 2-deoxynucleosidyl phosphorofluoridates and phosphorodifluoridates

Abstract

Tetra- and tri-coordinate P–N-imidazole derivatives and their structural analogues react smoothly with acyl fluorides to give the corresponding P–F compounds in almost quantitative yield. This method has been successfully applied to produce 2-deoxynucleosidyl phosphorofluoridates and phosphorodifluoridates.