The designed ribodinucleotide 1 containing a proximal imidazole, in the presence of ZnCl2, undergoes self hydrolysis faster than unmodified r(UpA); like its enzymatic counterpart, this reaction goes through the same steps of initial transesterification to 2′,3′-cUMP followed by hydrolysis to 2′- or 3′-UMP.
T. P. Prakash and K. N. Ganesh, J. Chem. Soc., Chem. Commun., 1994, 1357 DOI: 10.1039/C39940001357
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