A monoclonal antibody, elicited by a α,α,α′,α′-tetrafluoroketone hapten, acted as an enzyme-like catalyst for the hydrolysis of an analogous carbonate, demonstrating that the difluoromethylene unit can been used as an isostere and isoelectronic mimic for the oxygen atom in an ether.
T. Kitazume, T. Tsukamoto and K. Yoshimura, J. Chem. Soc., Chem. Commun., 1994, 1355 DOI: 10.1039/C39940001355
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