The Co atom can be methylated by reaction of the CoI cobalamin with the PhNMe3+ ion in aqueous solution at 25 °C at a pH-independent rate (pH 4–10) with the second-order rate constant k2= 2 × 10–3 dm3 mol–1 s–1.
J. M. Pratt, P. R. Norris, M. S. A. Hamza and R. Bolton, J. Chem. Soc., Chem. Commun., 1994, 1333 DOI: 10.1039/C39940001333
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