1,2-Asymmetric induction in radical-mediated allylation of diethyl (2S,3S)-3-bromo-2-oxysuccinates: efficient stereoselectivity enhancement by complexation with Eu(fod)3
Abstract
Allylation of diethyl (2S, 3S)-3-bromo-2-trimethylsilyloxysuccinate with allyltributyltin in the presence of Eu(fod)3 was found to give diethyl (2R, 3R)-3-allyl-2-trimethylsilyloxysuccinate with high diastereoselectivity [(2R, 3R): (2R, 3S)= 8.6:1].