A new and highly enantioselective synthesis of trans 5-substituted 2-hydroxymethylpyrrolidine derivatives is achieved by intramolecular radical cyclization at the 4-position of Δ4,5-oxazolidin-2-one, which leads to C2-symmetrical 2,5-dibenzyloxypyrrolidin-2-one.
Y. Yuasa, J. Ando and S. Shibuya, J. Chem. Soc., Chem. Commun., 1994, 455 DOI: 10.1039/C39940000455
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