Synthetic strategy for organometallic complexes of rhenium with exceptionally high affinity for the oestradiol receptor; their potential use as imaging and therapeutic agents

Abstract

Compounds such as 11β-chloromethyl-17α-[cyclopentadienyl (rhenium tricarbonyl)-ethynyl]-oestradiol are readily accessible, are stable in biological media and show very high affinity for the oestradiol receptor, offering, because of their potential use as radio-pharmaceuticals, new approaches in the treatment of breast cancer.