An efficient asymmetric induction at the γ-position to the carbonyl group of the chiral ester took place in 82% diastereoisomeric excess (d.e.)(87% yield) to afford chiral spiroisoxazoline by intramolecular oxidative cyclisation of o-phenolic oxime-ester 5 using hypervalent iodine reagent.
M. Murakata, K. Yamada and O. Hoshino, J. Chem. Soc., Chem. Commun., 1994, 443 DOI: 10.1039/C39940000443
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