Milbemycin spiroacetal 4 was prepared from (4S,5R)-4,5-dimethylpentan-5-olide 5 and (R)-1-(benzyloxymethyl)oxirane by alkylation and stereoselective reductive decyanation of the intermediate spiroacetal cyanohydrin 7.
S. D. Rychnovsky and G. Griesgraber, J. Chem. Soc., Chem. Commun., 1993, 291 DOI: 10.1039/C39930000291
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