Issue 3, 1993

The aquated form of cisplatin selectively attacks at the G[3] site in d(GTG)

Abstract

While d(GpTpG) reacts with cis-[Pt(NH3)2(OH2)(OH)]+ eventually to form a G[1]N(7), G[3](7) chelate, the initial attack is exclusively at G[3], (rate constants for the initial step and cyclisation being 21.6 dm3 mol–1 s–1 and 4.4 × 10–4 s, respectively at 37.0 °C).

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1993, 290-291

The aquated form of cisplatin selectively attacks at the G[3] site in d(GTG)

M. Garner, M. Green, N. Boogaard and J. Reedijk, J. Chem. Soc., Chem. Commun., 1993, 290 DOI: 10.1039/C39930000290

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