The efficiency of general acid catalysis by protonated amines of the hydrolysis of a phosphate diester with a neighbouring nucleophilic OH group depends less-on the pKa of the acid than on the proximity of a second positive charge.
K. N. Dalby, F. Hollfelder and A. J. Kirby, J. Chem. Soc., Chem. Commun., 1992, 1770 DOI: 10.1039/C39920001770
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