The synthesis of the diastereoisomeric lactones 12a and 12b as models for the carboxylate binding pocket of vancomycin is described; the structure of 12a, which corresponds to the diphenyl ether rotamer found in vancomycin, is established by X-ray crystallographic analysis.
R. B. Lamont, D. G. Allen, I. R. Clemens, C. E. Newall, M. V. J. Ramsay, M. Rose, S. Fortt and T. Gallagher, J. Chem. Soc., Chem. Commun., 1992, 1693 DOI: 10.1039/C39920001693
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