Stereocontrolled synthesis of calyculin A: construction of the C(26)–C(37) amide-oxazole unit
Abstract
(–)-B-[3-(Diisopropylaminodimethylsilyl)allyl]diisopinocampheylborane and Cornforth–Meyers chemistry, and Evans alkylation were employed to construct the C(26)–C(37) amide–oxazole unit of calyculin A.