An axially chiral NAD(P)H model 1 bearing a 2′-methoxy-1′-naphthyl group at the C-2 position is prepared; the reduction of methyl benzoylformate with the optically active model, (+)- or (–)-1, in the presence of magnesium ion gives (R)- or (S)-isomer of methyl mandelate, respectively, in over 95% enantiomeric excess.
M. Fujii, T. Kamata, M. Okamura and A. Ohno, J. Chem. Soc., Chem. Commun., 1992, 905 DOI: 10.1039/C39920000905
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