Issue 24, 1991

Probing the interaction of Hoechst 33258 with an A–T rich oligonucleotide duplex using 1H NMR spectroscopy

Abstract

Changes in the 1H chemical shifts values for resonances of the decanucleotide duplex d(GGTAATTACC)2 provide an NMR ‘footprint’ of the interaction of the synthetic dye Hoechst 33258 with the DNA minor groove.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1991, 1770-1771

Probing the interaction of Hoechst 33258 with an A–T rich oligonucleotide duplex using 1H NMR spectroscopy

K. J. Embrey, M. S. Searle and D. J. Craik, J. Chem. Soc., Chem. Commun., 1991, 1770 DOI: 10.1039/C39910001770

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