Biosynthesis of trichothecenes: oxygenation steps post-trichodiene
Abstract
Two dioxygenated derivatives of trichodiene 1 have been isolated from Fusarium culmorum cultures treated with the inhibitor ancymidol and characterized as 9,10-trichoene-12,13-diol 2 and 12, 13-epoxy-9, 10-trichoene-2-ol 3; radiolabelling experiments demonstrate that 2 is a dead-end metabolite whereas 3 is incorporated into both 3-acetyldeoxynivalenol 4 and sambucinol 7.