Heterocyclic derivatives 6 of (S)-glutamic acid, which are structurally related to key central nervous system (CNS) glutamate receptor agonists, are prepared from the aldehyde 9 using a novel reaction in which the pyroglutamate ring is cleaved in concert with formation of the new heterocyclic ring.
A. N. Bowler, P. M. Doyle and D. W. Young, J. Chem. Soc., Chem. Commun., 1991, 314 DOI: 10.1039/C39910000314
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