The nucleotide analogues 10, 13, 14 and 20 have been synthesised; the latter phosphonate was converted into the diphosphoryl-phosphonate 21 and this compound was shown to be a potent inhibitor of HIV-coded reverse transcriptase.
D. M. Coe, H. Hilpert, S. A. Noble, M. R. Peel, S. M. Roberts and R. Storer, J. Chem. Soc., Chem. Commun., 1991, 312 DOI: 10.1039/C39910000312
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