The addition of Grignard reagents to an N-acylated 3-chloro-4-morpholinopyridine followed by treatment with potassium t-butoxide provides a general route to 2-alkyl(aryl)-4-morpholinopyridines
M. A. Armitage and M. B. Mitchell, J. Chem. Soc., Perkin Trans. 1, 1990, 2848 DOI: 10.1039/P19900002848
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