Three di-, (Gly)2, (Val)2 and (Leu)2, and one tetra-peptide, (Gly)4, have been acylated with 2-chloroacetyl chloride and the resulting products treated with Cs2CO3 in dimethylformamide (DMF) solution; (Gly)2 and (Leu)4 provided strained 9-membered rings whereas (Val)2 dimerized to the 18-membered ring.
W. H. Kruizinga, R. Kingma, L. Leegstra, E. Rokaszewski, G. Gruppen and R. M. Kellogg, J. Chem. Soc., Chem. Commun., 1990, 1647 DOI: 10.1039/C39900001647
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