Issue 22, 1990
From the journal:

Journal of the Chemical Society, Chemical Communications

Conversion of dipeptides and a tetrapeptide to macrocyclic ionophores by means of caesium aided ring closure of the N-2-chloroacetyl derivatives

Wim H. Kruizinga,   Rob Kingma,   Libbe Leegstra,   Edward Rokaszewski,   Gert Gruppen  and  Richard M. Kellogg  

Abstract

Three di-, (Gly)2, (Val)2 and (Leu)2, and one tetra-peptide, (Gly)4, have been acylated with 2-chloroacetyl chloride and the resulting products treated with Cs2CO3 in dimethylformamide (DMF) solution; (Gly)2 and (Leu)4 provided strained 9-membered rings whereas (Val)2 dimerized to the 18-membered ring.

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Article information

DOI
https://doi.org/10.1039/C39900001647
Article type
Paper

J. Chem. Soc., Chem. Commun., 1990, 1647-1648

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Conversion of dipeptides and a tetrapeptide to macrocyclic ionophores by means of caesium aided ring closure of the N-2-chloroacetyl derivatives

W. H. Kruizinga, R. Kingma, L. Leegstra, E. Rokaszewski, G. Gruppen and R. M. Kellogg, J. Chem. Soc., Chem. Commun., 1990, 1647 DOI: 10.1039/C39900001647

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