Synthesis of tricyclospirodienones via spiroannulation; methodology for synthesis of aromatase inhibitors
Abstract
A new approach to the title ring system, required for the development of potential aromatase inhibitors, is described; acid chlorides (6) and (12) undergo an unusual addition–cyclisation reaction with alkynes, catalysed by aluminium chloride, to yield tricyclospirodienones (7) and (13).