The oxo ester (8), from the thiazolium salt catalysed conjugate addition of (S)-citronellal to ethyl acrylate, has been used in a synthesis of the cytochalasa-1,18,21-trione (3). This reacts both regio- and stereo-selectively with methylmagnesium chloride to provide the cytochalasin H precursor (4).
R. Sauter, E. J. Thomas and J. P. Watts, J. Chem. Soc., Perkin Trans. 1, 1989, 519 DOI: 10.1039/P19890000519
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