Incubation of [16,16,19-2H3][19-3H]-19-oxoandrost-4-ene-3,17-dione (2a) with microsomal aromatase gave inter alia[16,16-2H2]-10β-hydroxyestr-4-ene-3,17-dione (1), whose analogue (1b) on incubation with the aromatase gave 10β, 17β-dihydroxyestr-4-en-3-one (1d)(ca. 10%) and no estrogens which would indicate that (1b) is not an obligatory estrogen precursor.
E. Caspi, H. R. W. Dharmaratne and C. Shackleton, J. Chem. Soc., Chem. Commun., 1989, 1699 DOI: 10.1039/C39890001699
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