A novel approach to functionalised analogues of Cephalotaxine is described; the fused azaspirocyclic skeleton (11) has been constructed stereospecifically in nine steps (overall yield 15%) starting from 3,4-dimethoxy-carbomethoxymethyl-benzene.
M. R. Bryce and J. M. Gardiner, J. Chem. Soc., Chem. Commun., 1989, 1162 DOI: 10.1039/C39890001162
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