Asymmetric synthesis of functionalised pyrrolidines. The role of a stereogenic centre on nitrogen
Abstract
The diastereoselectivity available during the silver(I)-catalysed aminocyclisation of a series of allenic amines (1a–e) bearing a stereogenic residue on nitrogen, to give the 2-substituted pyrrolidines (2a–e), has been evaluated; the ability of this residue to co-ordinate AgI is important to the sucess of the process.