Enantioselective synthesis of (S)-γ-acetylenic γ-aminobutyric acid (GABA) and (S)-trans-γ-butenynyl GABA
Abstract
The enantioselective syntheses of (S)-γ-acetylenic γ-aminobutyric acid (GABA)(1) and the (E)-butenynyl analogue (2) by phthalimide displacement of the homochiral prop-2-ynylic alcohols (6) and (11)[generated from the acetals (3) and (9), respectively], are reported.