Micellar enhancement of benzodiazepine fluorescence

Abstract

The interactions that exist between benzodiazepines and surfactants provide micellar enhancement factors for their fluorimetric determination in the range 1.2–6.5, depending on the nature of both the benzodiazepine and the surfactant. A series of benzodiazepines and anionic surfactants were treated topologically to determine the influence of each benzodiazepine substituent on the basic benzodiazepine structure and the influence of both the hydrophobic moiety of the surfactant and its counter ion on the sensitisation process. Sensitisation parameters were used to quantify the effect of the chemical structures of both surfactants and drugs on their interaction.