Synthesis of conjugates of 11α-hydroxyprogesterone with β-nicotinamide adenine dinucleotide (β-NAD) and adenosine triphosphate (ATP)

Abstract

Conjugates of 11α-hydroxyprogesterone with adenosine triphosphate and nicotinamide adenine dinucleotide have been prepared in which the steroid is attached to the nucleotides via bridges from C-11 to the terminal phosphate and C-8 positions of ATP, and to the N-6 and C-8 positions on the adenine ring of NAD. Preliminary evaluation of the bioluminescence of these conjugates is reported.