Total synthesis of the ent-clerodane diterpenoids (±)-isolinaridiol and (±)-isolinaridiol diacetate
Abstract
A previously described mixture of bicyclo[4.4.0]decanecarbonitriles [(4) and (5)] was converted, via a nine-step sequence of reactions, into (±)-isolinaridiol (3), which was readily transformed into the corresponding diacetate (2).