Iodimetric determination of penicillins by a triangle programmed flow-through titration technique

Abstract

A flow-through triangle programmed titration technique for the determination of penicillin compounds has been developed. The hydrolysis of the penicillins and the titration procedure were performed under flow-through conditions. Electrolytically-generated iodine is used as the titrant and the detector system is a flow-through biamperometric type. Using the proposed method, the benzylpenicillin potassium content of a pharmaceutical preparation (Penicillin for Injection) has been determined.