Labelling studies (14C and 18O) have shown that the major biosynthetic pathway leading to the diterpenoid aphidicolin involves the aphidicolan-16β-ols whilst the results of 2H-labelling studies are consistent with a minor pathway involving epoxidation of an aphidicol-16-ene and hydrolysis of the epoxide.
M. J. Ackland, J. F. Gordon, J. R. Hanson, B. L. Yeoh and A. H. Ratcliffe, J. Chem. Soc., Chem. Commun., 1987, 1492 DOI: 10.1039/C39870001492
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